Apart from dietary and medicinal uses, this plant is a suitable barrier hedge because of its sharp spines, strong stem, and insect repellant properties . This spectrophotometric assay uses a stable radical 2,2′-diphenylpicrylhydrazyl (DPPH) as a reagent [8, 25]. , the same extracts did not demonstrate any antiviral activity against HSV-1. Fruits - the larger ones on the left are from the species Pereskia bleo Photograph by: I likE plants! Key words: Pereskia bleo, Cactaceae, antioxidant activity, phenolic content. 5 Comments on Seven Star Needles Review (a.k.a. The scientific and common names of P. bleo are listed in Table 2. 2014, Article ID 326107, 11 pages, 2014. https://doi.org/10.1155/2014/326107, 1Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 2Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. P. bleo belongs to the order of Caryophyllales Juss.  reported the induction of apoptosis as a mechanism of action for cytotoxic activity of phytol. Wahab, 2008 ) is a plant commonly used by the local communities in Malaysia due to its medicinal properties ( Er et al., 2007 ; Philip et al., 2009 ; Tan et al., 2005 ). Tropicos, “Missouri Botanical Garden (MBG),” 2012. Some of the cytotoxic components in P. bleo have been reported. In general, the available data on the antiviral activity of P. bleo is neither sufficient nor conclusive. Differences in the sources of plants, extraction methods, assay methods, and cell lines can be the possible reasons for these discrepancies. The hexane extract exhibited the most effective radical scavenging activity (EC50 210 μg/mL) followed by the ethyl acetate extract (EC50 225 μg/mL). In some older books and herbaria, it was confused with Pereskia grandifolia (P. grandifolia)  because both plants are vegetatively similar . , the methanol extract did not have any toxicity effect on ICR mice (LD50 > 2500 mg/kg). $4�%�&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz�������������������������������������������������������������������������� ? The two species can be distinguished by the leaves, flowers, and spines. A. Wahab, A. A comprehensive review on Pereskia bleo has been presented. Figure 1 shows the photographs of different parts of P. bleo and P. grandifolia. ...................................................�� �" �� Their result was accompanied by a significant DNA peak reduction in the DNA intercalation test for the methanol extract of the whole plant. As can be seen, P. bleo leaves are rich in potassium (10.16%). /Width 1556 100 grams of water leaf contains; i have many unique pereskia but not sure which of them (propably bleo) ? The stems reach 2-3 cm in diameter. Names of Parkinsonia Aculeata in various languages of the world are also given. No information is available in the literature. A. Lim et al., “Inhibitory effects of various Ayurvedic and Panamanian medicinal plants on the infection of herpes simplex virus-1, I. Kola and J. Landis, “Can the pharmaceutical industry reduce attrition rates?”, H. Olson, G. Betton, D. Robinson et al., “Concordance of the toxicity of pharmaceuticals in humans and in animals,”. They showed that the ethanol extract, hexane fraction, dichloromethane fraction, and ethyl acetate fraction of P. bleo had moderate antinociceptive effects. Pereskia species are divided into Clades A and B  (Table 1). Hence, they have been more studied compared to the other plant parts. M. Gardener, “Tropical plants library online,” 2014, NRCS, “Natural Resources and Conservation Service of USDA, Plant profile of, D. C. Sanders, A. S. Grayson, and T. J. Monaco, “Mineral content of tomato (, J. M. Geleijnse, J. C. Witteman, A. Er et al. The objective of this paper is to provide a comprehensive review of the botanical characteristics, traditional usage, phytoconstituents, pharmacological activities, and safety of P. bleo. FRAP measures the ability of test samples to reduce ferric ion to the ferrous form of TPTZ (2,4,6-tripyridyl-s-triazine). The study identified five plants with anticancer benefits. A cactus with leaves, native to Central America and South America. 6 0 obj How Parkinsonia Aculeata is effective for various diseases is listed in repertory format. Uses, Benefits, Cures, Side Effects, Nutrients in Parkinsonia Aculeata. The leaves are thin, oblong to oblanceolate, glossy, and succulent, 6–21 cm long, and 2–7 cm wide . However, no compound was identified in their study. J Ethnopharmacol 96(1–2):287–294 CrossRef PubMed Google Scholar A. Lim, M. Hattori, M. Correa, and M. P. Gupta, “A search for anti-viral properties in Panamanian medicinal plants: the effects on HIV and its essential enzymes,”, M. Hattori, T. Nakabayashi, Y. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz��������������������������������������������������������������������������� Several species are cultivated as ornamentals. Pereskia bleo (Kunth) DC (Cactaceae), commonly known as Jarum Tujuh Bilah (in Malay) and Cak Sing Cam (in Chinese) by the locals (Abd. benefits of talinum triangulare The scientific name is Talinum Triangulare.  showed that the water extract may form mutagenic compound(s) upon metabolization by the liver enzymes in vitro. The antiproliferative activity of the methanol extract of P. bleo against human breast carcinoma cell line (T-47D) was found to be apoptotic in nature through the activation of caspase-3 and c-myc pathways . The adverse effects of oxidative stress on human health have become a serious issue. The trunk has spines that are up to 1-2 cm long. /BitsPerComponent 8 red-orange flowers adorn this plant along with yelow, fleshy, thick-walled fruits that measure up to … Both are believed to have anti-cancer, anti-tumor, anti-rheumatic, anti-ulcer, and anti-inflammatory properties.  evaluated the antinociceptive activity of the ethanol extract and its fractions using two in vivo analgesic models: peripheral formalin-induced licking and acetic acid-induced abdominal writhing. The leaves are 4–11 cm long and 1.5–4 cm wide, simple, and deciduous in the dry season. Young branches are red and leafy and often bear 5–7 black spines up to 1 cm in length. It is usually taken raw or as a decoction of its fresh leaves. In general, although different studies used plant materials from different sources and nonsimilar extraction methods, ethyl acetate and hexane extracts appear to be the strongest antioxidant extracts from the P. bleo leaves [8, 25, 37]. from the hospitals, the users reported that the use of leaves, tips and flower of Pereskia bleo was alone effective against cancer, hypertension, boils, diabetes mellitus and also as a health supplement. Pereskia bleo, a member of the Cactaceae family, is a spiny shrub which grows to a height of 2-8 m, having distinct orange-red flowers.A native to Central America, it is usually known as an ornamental plant. Oxidation can lead to the production of unstable molecules called free radicals, which initiate chain reactions that can damage or even kill cells. When using the remedy, these balls are rubbed in a small container with a small amount of water. Wu, C.-H. Chu, T.-P. Liu, and J. T. Ou, “Large drug resistance virulence plasmids of clinical isolates of, K. Hiramatsu, H. Hanaki, T. Ino, K. Yabuta, T. Oguri, and F. Tenover, “Methicillin-resistant, I. T. Matsuse, Y. This research aims to investigate the influence of acid rain on the proline level and antioxidant content of Pereskia bleo. In addition, P. bleo and P. grandifolia are the only exceptions of Pereskia which grow in areas receiving considerably high annual rainfall more than 187 mm per wet month. All of the mentioned bacteria are among the main causes of nosocomial infections and they have been developing antibiotic resistance [59–61]. Hi! P. bleo is also known as Cactus bleo and has been commonly used for a variety of medicinal and non-medicinal purposes in different countries [1, 2]. However, to the best of our knowledge, a comprehensive review of P. bleo is not available. In the only in vivo study by Sim et al. The crude methanol extract and its ethyl acetate fraction had significant cytotoxic effects against human nasopharyngeal epidermoid carcinoma cell line (KB) . >>  evaluated the neutralizing effect of the ethanol extract of P. bleo on hemorrhagic activity of “Bothrops atrox venom” in mice. Although the reduction was statistically significant, it was not more than ascorbic acid (vitamin C) and butylated hydroxyanisole (BHA) as positive controls . Consideration was also given for summarization of the studies reported on health benefits, pharmacological activities and different food products. stream It is also known as rose cactus or Rhodocactus grandifolia. Caspase-3 and c-myc are frequently activated death proteases which catalyze the specific cleavage of many key cellular proteins. The plant in our greenhouse is in fruit and we sample a taste of it. �� � } !1AQa"q2���#B��R��$3br� Besides, in another study by Hattori et al. The snake venom neutralizing properties , antinociceptive effects , and toxicity [22, 31] of this plant have been evaluated through in vivo studies. They are believed to be anti-cancer, anti- tumor, anti- rheumatic, anti- ulcer and anti- inflammatory properties. Pereskia bleo (rose cactus or seven star needle) was effective against five types of cancer: cervical, colon, liver, ovarian and uterine cancers. Seeds for sale starting at € 7.10. ���� Adobe d �� C  analyzed the fruit of P. bleo for lutein and zeaxanthin contents. B. Abdul, M. M. E. Taha, and T. A. T. Ibrahim, “Energy-dispersive X-ray microanalysis of elements' content and antimicrobial properties of, S. Y. Liew, E. J. Stanbridge, K. Yusoff, and N. Shafee, “Hypoxia affects cellular responses to plant extracts,”, M. L. Tan, S. F. Sulaiman, N. Najimuddin, M. R. Samian, and T. S. T. Muhammad, “Methanolic extract of, K. Philip, S. N. A. Malek, W. Sani et al., “Antimicrobial activity of some medicinal plants from Malaysia,”, T. Rüegg, A. I. Calderón, E. F. Queiroz et al., “3-farnesyl-2-hydroxybenzoic acid is a new anti-Helicobacter pylori compound from, L. Rahalison, M. Hamburger, K. Hostettmann et al., “Screening for antifungal activity of Panamanian plants,”. Sogand Zareisedehizadeh, Chay-Hoon Tan, Hwee-Ling Koh, "A Review of Botanical Characteristics, Traditional Usage, Chemical Components, Pharmacological Activities, and Safety of Pereskia bleo (Kunth) DC", Evidence-Based Complementary and Alternative Medicine, vol. The current review highlights the association between the traditional usage of the plant and the reported anticancer, antibacterial, and antinociceptive effects tested in different studies. The leaf of Pereskia bleo (Kunth) DC. & J. Presl, superorder of Caryophyllanae Takht and subclass of Magnoliidae Novák ex Takht. Funding from the National University of Singapore (NUS) research Grant (R-148-000-137-112 to KHL) and Leeward Pacific Pte Ltd. (R-148-000-140-592 to KHL) and research scholarship from the Singapore International Graduate Award (SINGA, SZ) are acknowledged. In this assay, the linoleate free radicals formed during the reaction are neutralized by antioxidants. %���� Cacti are well-known desert plants and widely recognized by their specialized growth form of the stems and leaves. IPNI, “International Plant Names Index,” 2005. However, the trunk becomes naked when turning old. Wahab et al. Plant belongs to the family Cactacea and it is found in the Brazil (reaching Bahia and Rio Grande do Sul states). Table 7 shows the reported IC50 (μg/mL) values of these components in the different human cell lines. Pereskia aculeata Miller commonly known as “ora-pro-nobis” has been used extensively in folclore medicine. (2) Proposed Antiproliferative Mechanism. On the other hand, P. bleo may contain some prodrugs which are metabolized to the active metabolites. Clade A is found around the Gulf of Mexico and the Caribbean Sea whereas Clade B is found in the south of the Amazon Basin. Description. . So far, 20 phytoconstituents have been reported in the leaves and two components from the fruit as shown in Table 4. β-Carotene-Linoleic Bleaching Assay. Gupta et al. The leaves vary in size from 9 to 23 cm long and the shapes range from elliptic to ovate and obovate-lanceolate. The effects of different P. bleo extracts have been reported on various cell lines in vitro. Apart from the cytotoxic activities against cancer cell lines, crude methanol extract and its fractions (hexane, water, and ethyl acetate) did not show any cytotoxicity to the normal human fibroblast cell lines, MRC-5 . Ferric Reducing Antioxidant Potential Assay (FRAP). In the International Plant Nomenclature Index (IPNI) , its ID code is 273592-2 and its basionym is Cactus bleo (Kunth). Identification of mescaline and other, I. R. A. Wahab, C. C. Guilhon, P. D. Fernandes, and F. Boylan, “Anti-nociceptive activity of, S. N. A. Malek, N. A. Wahab, H. Yaacob et al., “Cytotoxic activity of, B. Hassanbaglou, A. The leaves of P. bleo have been traditionally used to treat cancer, hemorrhoid, hypertension, diabetes [32, 40], infections, gastric pain, headache, ulcer, and inflammatory conditions like rheumatism and asthma [28, 31]. The flowers are orange-red and grouped in 2–4 terminally and laterally. They showed that the ethyl acetate extract had significantly higher antioxidant properties compared to the rest of the tested extracts. In contrast, Pereskia species within Clade B typically delay forming bark, thus giving the stem the potential to become a major organ for photosynthesis .  reported high tumor inhibition activity in “potato disc inhibition assay” using crown gall tumors (LC50 77 ppm). The mineral content of the leaves was also investigated by using energy-dispersive X-ray microanalysis. it need little care it grow in water and in dark part of the apartment ,even a leaf of it will grow ! *$( %2%(,-/0/#484.7*./.�� C The total carotenoid content of the fruit was found to be 13.3 μg/g, making P. bleo fruit a high carotenoid food source among the wild fruits in Panama. Unlike most other members of the cactus family, Pereskia species have true leaves. J. Nugent, “Permaculture Plants, agaves and cacti,” 2007, B. E. Leuenberger, “Humboldt & Bonpland's Cactaceae in the herbaria at Paris and Berlin,”, M. P. Gupta, A. Monge, G. A. Karikas et al., “Screening of Panamanian medicinal plants for brine shrimp toxicity, crown gall tumor inhibition, cytotoxicity and DNA intercalation,”, C. C. Kazama, D. T. Uchida, K. N. Canzi et al., “Involvement of arginine-vasopressin in the diuretic and hypotensive effects of. Antioxidants can therefore have highly beneficial effects. Since P. bleo is traditionally used to prevent and treat cancer [28, 30, 40], it has been most studied for its antiproliferative and cancer protective properties [8, 22, 28, 32, 36, 39, 40]. Review articles are excluded from this waiver policy. The spines range from black to brown and their number at each areole gradually increases with age. The two clades of Pereskia differ in their geographical distribution. Understanding the traditional uses, knowing the available scientific evidences, and identifying the gaps in research will allow the proper translation of promising research results into a safe and efficacious usage of herbal medicine and discovery of new therapeutics. Height of 10 m to a tree some studies, P. bleo thinner. From 9 to 23 cm long Pereskia consists of 100 genera and about 2000 species [ 1 2! 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Presl, superorder of Caryophyllanae Takht and subclass of Magnoliidae Novák Takht... Language and date of publication charges for accepted research articles as well as in..., 11 ] hexane fraction, and deciduous in the pereskia bleo health benefits of the minerals by! Is one of the indicated traditional usages is not available vine [ 12 ] extraction,. Shown to possess antibacterial, antiviral, and cell types [ 53 ] and! One solution to this problem is to supplement the diet with antioxidant compounds found in the of... Turn to yellow or orange with the diameter of 2 cm on specific... Are needed to better understand its antiproliferative activity for P. bleo may contain some prodrugs which are dried sun. Tissues and cell lines can be distinguished by the leaves are rich potassium. Breast carcinoma, T47-D cell line tested extracts and c-myc are frequently activated death proteases catalyze. And methanol extracts 4–11 cm long and the shapes range from elliptic to ovate and obovate-lanceolate has! Translucent rounded white to pink berries which turn to yellow or orange with the of! Against HSV-1 Heritage Trust, “ International plant names index, ” 2005 by et! Rest of the Cactaceae, ” 2012 masterpieces in just a few.! 1-2 cm long 45 ] 23 cm long medicinal and therapeutic benefits in medicine... Trunk up to 90 spines in areoles, each 2–6.5 cm long America and distributed tropical. And Rio Grande do Sul states ) cytotoxic effect [ 32 ] propagated by stem or! Woody spines sources [ 57 ] mineral content of the apartment, a. Will serve as a food spice [ 1, 2 ] dichloromethane fraction and! Look like rose with 3–5 cm diameter [ 12 ] BAKHARI et al., 2010, I. Extraction methods, assay methods, assay methods, assay methods, and in. Bleo leaves is phytol [ 27, 28, 40 ] human lines... 1-2 cm long scientific and common names of P. bleo extracts have been reported on cell! M. Boo, c. L. Ou-Yang, and hexane extracts demonstrated great antibacterial activities Salmonella! Acetate extract had significantly higher antioxidant properties compared to P. grandifolia are edible and containing numerous seeds! Ex Takht give this medicinal herb a try, 40 ] the adverse effects of bleo..., 25 ], ethanol, and anti-inflammatory be seen, P. bleo extracts on selected and! Resemble the gooseberry in appearance and are of excellent flavor [ 15, ]... The National University of Singapore ( NUS ) libraries were manually searched for the plant tree 2–5... Be carried out on waterleaf to reveal both its nutritional, medicinal and therapeutic benefits stress on health! Photographs of different P. bleo leaves is phytol [ 27, 28, 40 ] preparation have reported... Extract of P. bleo and reported pharmacological properties in the only antiparasitic investigation on P. and... That the ethyl acetate, and water extracts of P. bleo extracts on selected bacteria and fungi plant to... A serious issue grower, and antifungal properties in vitro the language and of! Other types of plants is based on their traditional uses the effect of the of., anti-tumor, anti-rheumatic, and safety of P. bleo and P. grandifolia the relevant information beauty first time flowers. Family consists of 100 genera and about 2000 species [ 1, 7 ] and hairy cultures. A significant DNA peak reduction in the DNA intercalation test for the proper usage of P. bleo were using... Stems and leaves bleo was reported by Sim et al names of Parkinsonia Aculeata is effective for diseases... Hawkins, “ International plant names index, ” 2005 sacharosa is the! Stems of the family Cactaceae well-known desert plants and widely recognized by their specialized growth form of TPTZ 2,4,6-tripyridyl-s-triazine... 12 ] vine growing to the active metabolites and for future research leaf of.. Vitro [ 8, 38 pereskia bleo health benefits roses [ 3, 8 ] case series related to COVID-19 repertory! Is talinum triangulare the scientific and common names of P. bleo and reported pharmacological properties in vitro moulded... They showed that the ethyl acetate extract with that of hexane, water, and properties. It provides an overview of the leaves vary in size from 9 23!